Moral Stem Cell Research
Scientific breakthrough expected to advance ethical stem cell research
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.- Pro-life and church groups are optimistic about a new scientific breakthrough that provides yet another ethical alternative to embryonic stem cell research, reports  Time Magazine.

According to the scientific journals Nature and Cell Stem Cell, researchers have succeeded in reprogramming ordinary cells from the tips of mouse tails so they are virtually indistinguishable from embryonic stem cells.


Three research groups said they accomplished their feat in mature cells by turning on four genes that are always active in days-old embryos. Some of the rejuvenated cells were able to mature into new mice, demonstrating the cells' ability to create every type of tissue in the body.

Researchers are optimistic that the discovery can be applied to human cells, which would offer an ethical way to create a limitless supply of cell lines tailor-made for patients.

"This would be a win for science, ethics and society," said Richard Doerflinger of the U.S. bishops’ Secretariat for Pro-Life Activities. "It may offer a way for people of all faiths and all ethical backgrounds to study, use, subsidize and enjoy any therapeutic benefits of … stem cell research."

Researchers say the method for human cells could eventually start by simply taking a cheek swab or some skin cells, and turning them into stem cells in a laboratory.


While researchers admit that there are lots of technical hurdles to overcome, reprogrammed cells could become the long-sought ethical substitute for embryonic stem cells.

This ground-breaking research was based on a Japanese study at Kyoto University, published last year, in which cells from the tails of adult mice were reprogrammed to become "pluripotent" — able to grow into many kinds of tissues.

In one of the new studies, published in the journal Nature, the Japanese scientists modified their procedures and succeeded in reversing the cell development toward an embryonic stage — which they were not able to do previously. When the resulting cells — which they dubbed induced pluripotent stem cells, or iPS cells — were injected into mouse embryos, they contributed to the development of all parts of the animals.

Some of their offspring also inherited genes from the iPS cells. Senior author Dr. Shinya Yamanaka, from Kyoto University's stem cell biology department, said that genetic inheritance was an important sign because only cells that behave like embryonic stem cells can be passed from parent to child.

While the new Japanese study presented numerous positive results, more than 10 percent of the mice used in the study developed tumors—an obstacle that must be tackled in future research.

As a result, some scientists are concerned that it is too premature to use this method in humans because it might pose a health risk.

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Subscriber comments:
Published by: Kathleen Clark
Antrim, NH 07/07/2007 08:27 AM EST
Yes, this is very interesting and hopefully can produce what is needed to help those who are truly suffering. However, the technology in your article is taking science three steps back. As it states at the end of the article there are many hurdles to over come before getting anywhere near human use.
We already have embryonic stem cells and should be doing extensive research on those right now to find cures to diseases and injuries. Once this is accomplished and we begin to help the suffering, we should then begin to refine our methods for obtaining these cells like mentioned in this article to appease all who feel it's unethical. The cells used now are left over from fertility clinics and are going to be thrown away in biohazard bags. Why not give these human embryonic stem cells a purpose to help mankind and those who are suffering? Why keep debating this issue while people with ALS, spinal cord injuries, diabetes and many other horrific illnesses suffer just to satisfy the ideology of a few?
It breaks my heart to see my 23 year old daughter, whose goal in life was to become a nurse and help those suffering, roll around the corner in her electric wheelchair with tears streaming down her face saying. "Why does President Bush care more about a group of 30 to 150 cells in a petri dish more than me and millions of suffering Americans?"
Don't use this science to stall another that can help sooner. Use it together to come up with a answer and then refine it!
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