The estate property has ten buildings with close to 229,000 square feet of living and workspace.
According to the sisters, the decision to sell these properties will help advance the mission of St. Katharine Drexel.
Sr. Breslin said the order will rededicate its resources to "our mission serving some of the most vulnerable people in the United States, Haiti and Jamaica."
"We also will use proceeds from the sales to challenge, in new ways, all forms of racism as well as the other deeply rooted injustices in the world," she said.
The congregation's administrative offices will move, and the community's retired sisters will also benefit from the sale of the property.
The sisters have contracted with a firm to relocate the approximately 50 sisters now living at the Motherhouse, many of whom are in their 80s and 90s and in nursing care.
St. Katharine Drexel's corpse will be moved to Philadelphia's Cathedral Basilica of Sts. Peter and Paul and placed near the altar that already honors her.
The archdiocese will take control of many of the archives of the Sisters of the Blessed Sacrament.
"The sisters have gone through much careful discernment and study prior to this decision," Archbishop Chaput said. "I applaud their careful forethought and efforts to ensure that they can carry on the mission and vision established by Saint Katharine Drexel."
"When the time is right to do so, the remains of Saint Katharine Drexel will be transferred to the care of the Archdiocese and entombed in an appropriate location in the Cathedral Basilica of Saints Peter and Paul," he said. "It is both an honor and a blessing to accept this responsibility."
Sr. Breslin said that the relocation of the saint's remains will be like a return "to her second home."
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"The cathedral is where her family worshipped, and it's where she formed her faith," she told the Philadelphia Inquirer.