"Let us walk together along the Way of the Cross and let us do so carrying in our hearts this word of love and forgiveness," the Pope said.
"Let us go forward waiting for the Resurrection of Jesus," he added.
Pope Francis also thanked his Lebanese "brothers and sisters" for their witness and for writing the "beautiful" reflections that were read during the prayer.
"When Pope Benedict visited Lebanon, we saw the beauty and the strong bond of communion joining Christians together in that land and the friendship of our Muslim brothers and sisters and so many others," he said.
"That occasion was a sign of hope to the Middle East and to the whole world," he said.
He acknowleged that sometimes it seems as though God does not react to evil, "as if he is silent."
"And yet God has spoken, he has replied, and his answer is the Cross of Christ, a word which is love, mercy, forgiveness," said the pontiff.
But it is also reveals a judgment and that God, in judging us, loves us.
"If I embrace his love then I am saved, if I refuse it, then I am condemned, not by him, but my own self, because God never condemns, he only loves and saves," remarked the Pope.
Pope Francis thanked those present at the Coliseum for taking part "in these moments of deep prayer," as well as the media, the sick and the elderly.
He will preside over Easter Vigil Mass tomorrow at 8:30 p.m., when he will baptize four people, including a 17-year-old Vietnamese American.
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The Pope will not give a homily on Easter Sunday, but he is expected to give the Urbi et Orbi greeting in 65 languages after the 10:30 a.m. Mass.