The account will include tweets in seven languages besides English. Those languages are Spanish, Arabic, German, Polish, French, Portuguese and Italian.
The president of the Pontifical Council for Social Communications, Archbishop Claudio Maria Celli, said that he "loves it that the Pope will have a Twitter account, and it's going to portray what he carries in his heart."
"He wants to be, in a discrete way, involved in man's search for answering questions," Archbishop Celli remarked. "He has a desire to dialogue with man and help him find again a meaning for his own life."
But critics question how the Pope's messages can be reduced to only 140 characters.
"That's not my problem," Archbishop Celli replied. "My problem is to give a profound human depth to our communication," he added.
"I don't want to give an excessive tribute to modernity nor advertise Twitter, but it's our desire to enter into dialogue with the men and women of today."
Currently with 1 billion people or one-seventh of the world's population uses Facebook, in contrast with Twitter's 500 million users.
But Burke thinks that Pope Benedict XVI will reach more people this way and that a Facebook account would be "too personal."
"I would be surprised if someone like the Pope who speaks so much publicly didn't have a Twitter account," he said.
"His page will change from time to time depending on the season, so now it'll be related to Advent," added Burke.
The Secretary of State media advisor also foresees the Twitter account being "extremely helpful to follow up on emergencies."
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Archbishop Celli noted that most Twitter users are aged 18 to 34, and that the Pope wants to better engage with that segment of the population.
Pope Benedict's English-language Twitter account had 158,000 followers as of Monday evening at 6:30 p.m. Rome time.