Cardinal Tagle was born in Manila on June 21, 1957.
He was ordained a Priest on February 27, 1982 for Imus, Philippines, and on October 22, 2001 he was appointed Bishop of Imus, Philippines. He was ordained Bishop on December 12, 2001.
On October 13, 2011 he was appointed Archbishop of Manila, Philippines, and was installed on December 12, 2011.
He was elevated to Cardinal on November 24, 2012 and appointed Cardinal-Priest of San Felice da Cantalice a Centocelle.