Cardinal Prosper Grech was born in Vittoriosa (Birgu), Malta on December 24, 1925.
On October 8, 1944 he made his profession as a member of Order of St. Augustine, and was ordained a Priest with the order on March 25, 1950.
On January 18, 2012 he was appointed Titular Archbishop of San Leone, and was ordained Bishop on February 8, 2012.
On February 18, 2012 he was appointed Cardinal-Deacon of Santa Maria Goretti and elevated to Cardinal. He was installed on April 21, 2012.