On August 24, 1562 she founded the convent of Discalced Carmelite Nuns, a reform of the Carmelite order so radical and strict that it caused much violent opposition. However, with the grace of God she prevailed and founded many other similar convents.
She befriended St. John of the Cross and with him undertook similar reforms with the Carmelite friars.
After suffering to the end with painful illnesses and the exhaustion from carrying out God’s work, she died on October 4, 1582. Her body and transverberated heart are still incorrupt in Alba, Spain where she died.
On September 27, 1970 she was proclaimed the first ever woman Doctor in the history of the Church by Pope Paul VI.