Nathanson was previously a strong proponent of legalized abortion, and has been accused of inflating statistics on illegal abortions in the U.S. In 1969, he helped to found the lobbying organization now known as NARAL Pro-Choice America.
He left the practice of abortion in the early 1970s, and became a Christian and a pro-life activist until his death in 2011.
Loeb said he experienced an evolution of his own views on abortion similar to that of Nathanson. As a young man, he was pro-choice; in his 20s, he had two partners who obtained abortions.
“[I]t really had an emotional impact on me. As I've gotten older, the more regret I have. If I knew then what I know now, I wouldn't have had them,” he commented.
“Learning more about the science behind it and when a human being is actually created, I slowly started to change my views. I went on the same journey as Bernard [Nathanson] and that's why I was really interested in playing this role.”
Several of the film’s other stars are also known to be pro-life, such as Jon Voight, who stars as Supreme Court Chief Justice Warren Burger.
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In 2020, "Roe v. Wade" premiered at the Vienna Independent Film Festival, where Voight took home the award for best supporting actor, the Federalist reported.
Loeb said not all the actors in the film are pro-life, but at least one of the actors— whom he declined to name— converted from pro-choice views to pro-life over the course of filmmaking.
Loeb said writing the film took extensive research into the Roe v. Wade case, and it was important to him to have a female co-writer, rather than him alone.