Those factors led to calls for Wuerl's resignation and demonstrations outside of his Washington residence.
After Wuerl made a trip to Rome in late August, media reports said that Pope Francis had instructed the cardinal to consult with Washington clergy about the best way forward for him and the archdiocese.
In a Sept. 11 letter to DC priests written after a private meeting with them, Wuerl said that he would soon meet with the pope to discuss his future, but did not immediately state that he would ask the pope to allow him to resign. A spokesman for Wuerl confirmed to CNA Sept. 12 that the cardinal intended to formally ask Pope Francis to allow him to step down.
It is widely believed that Wuerl hoped to remain in his position at least until the fall meeting of the U.S. bishops' conference in November. That session is expected to focus on the fallout of the recent sexual abuse crises, and Wuerl is said to want to play an active part in helping the Church respond.
As apostolic administrator, Wuerl will continue to lead the day-to-day activities of the archdiocese, but will not be permitted to make any major changes.
If a successor is not appointed and installed before Nov. 13, the apostolic administrator will attend the bishops' conference annual meeting as the representative of the Archdiocese of Washington.
The auxiliary bishops of Washington also released a statement Friday, saying the cardinal's "pastoral and spiritual leadership in the archdiocese is well appreciated."
"We believe that Cardinal Wuerl's decision to request that the Holy Father, Pope Francis, accept the resignation he first offered years ago is a clear manifestation of his love and concern for the people of this archdiocese," wrote Bishops Mario E. Dorsonville, Roy E. Campbell Jr., and Michael W. Fisher.
Kim Viti Fiorentino, chancellor and general counsel of the Archdiocese of Washington, said in a statement Oct. 12 that the archdiocese has "been profoundly blessed to have this great priest as our archbishop."
"His final decision to act in favor of the people he loved and served for twelve years is the most eloquent witness to the integrity of his ministry and his legacy," she continued. "I am truly thankful for his steadfast fidelity and his courageous and sacrificial commitment to the future of the Church in Washington."
A native of Pittsburgh, Penn., Wuerl studied at the Catholic University of America in Washington, D.C. and at the Pontifical Gregorian University in Rome. He was ordained a priest for the Diocese of Pittsburgh in 1966 and went on to receive a doctorate in 1974.
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In the 1990s Wuerl hosted the television program, "The Teaching of Christ." He also wrote a best-selling adult catechism of the same name, and has since more than 20 other books.
Wuerl was appointed an auxiliary bishop in the Archdiocese of Seattle in 1986, following a Vatican investigation into Seattle's Archbishop Raymond Hunthausen. Wuerl was charged with special responsibility for five problem areas in the archdiocese: liturgy, the tribunal, priest formation, moral and bioethical issues in Catholic hospitals, and ministry and teaching concerning homosexuality. The appointment generated serious conflict among Hunthausen's supporters, and Wuerl was relieved of his responsibility in 1987.
He was appointed Bishop of Pittsburgh in 1988. He held this position until he was appointed in May 2006 to head the Archdiocese of Washington. He was named a cardinal by Pope Benedict XVI on Nov. 20, 2010.
The Wall Street Journal reported Friday that front runners to replace Wuerl include Cardinal Joseph Tobin of Newark, Bishop Robert McElroy of San Diego, and Bishop Frank Caggiano of Bridgeport, Connecticut.
Wuerl is a member of several Vatican departments, including the Pontifical Council for Promoting Christian Unity and the Congregation for Bishops.
CNA's Courtney Grogan contributed to this report.