"We've never joined such commissions that require us to accept our non-Muslim status," he said.
Minister of Information Shibli Faraz has said the rights of all people were fully respected in the handling of the commission.
"Every country has the sovereign right to make judgments according to its ground realities," he told Reuters.
Khan, the Minister for Parliamentary Affairs, had posted to Twitter, then deleted, a comment "There is only one punishment for insulting the Prophet - chopping off the head." He said he believed in "legal procedures and court proceedings" for those accused of blasphemy. Twitter told him to delete the post, Reuters reports.
Pakistan's blasphemy laws impose strict punishment on those who desecrate the Quran or who defame or insult Muhammad. Although the government has never executed a person under the blasphemy laws, accusations alone have inspired mob and vigilante violence.
The laws, introduced in the 1980s, are reportedly used to settle scores or to persecute religious minorities. While non-Muslims constitute only 3 percent of the Pakistani population, 14 percent of blasphemy cases have been levied against them.
Many of those accused of blasphemy are murdered, and advocates of changing the law are also targeted by violence.
The Governor of Punjab Salman Taseer was one such critic of the law who was assassinated in January 2011.
Just months later, in March 2011, Shahbaz Bhatti, the first Federal Minister For Minorities Affairs and the only Christian in Pakistan's cabinet, was assassinated by extremists who characterized him as a blasphemer. Bhatti had criticized the law and defended Asia Bibi, a Catholic woman sentenced to death by hanging in 2010 for blasphemy.
Bibi spent nine years on death row, but left Pakistan for Canada in 2019 at the age of 53 after her death sentence was overturned in October 2018.
The verdict and her subsequent release from prison sparked protests from Islamic hardliners who support strong blasphemy laws.
(Story continues below)
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In Punjab last year, a mob attacked a Christian community after a mosque broadcast over loudspeaker a claim that the Christians had insulted Islam. In another incident in Karachi, false blasphemy accusations against four Christian women prompted mob violence that forced nearly 200 Christian families to flee their homes, the U.S. Commission on International Religious Freedom said.
The situation in Pakistan has attention from some prominent Catholics.
In a Jan. 21, 2020 letter written on behalf of Philadelphia's Pakistani Catholic community, then-Archbishop of Philadelphia Charles J. Chaput encouraged Pakistan's Prime Minister Imran Khan to shape a culture of religious freedom
The U.S. Commission on International Religious Freedom's latest annual report said religious freedom conditions in Pakistan continued to deteriorate last year, citing "The systematic enforcement of blasphemy and anti-Ahmadiyya laws, and authorities' failure to address forced conversions of religious minorities-including Hindus, Christians, and Sikhs-to Islam."
The bipartisan federal commission advises the U.S. government on policy. Its report recommended that the U.S. government name Pakistan a country of particular concern for "systematic, ongoing, and egregious violations of religious freedom."
In December 2018, for the first time, the U.S. State Department designated Pakistan a "Country of Particular Concern." The designation, which can trigger sanctions under U.S. law, had been recommended by the U.S. Commission for International Religious Freedom in 2017 and 2018.