"There are ways that do not lead to heaven: the ways of worldliness, the ways of self-assertion, the ways of selfish power," he said.
"And there is the way of Jesus, the way of humble love, of prayer, of meekness, of trust, of service to others. It is to go ahead every day asking: 'Jesus, what do you think of my choice? What would you do in this situation, with these people?'"
"It will do us good to ask Jesus, who is the way, the directions for heaven. May Our Lady, Queen of Heaven, help us to follow Jesus, who opened heaven for us."
After reciting the Regina Coeli, the pope recalled two anniversaries.
The first was the 70th anniversary on May 9 of the Schuman Declaration, which led to the creation of the European Coal and Steel Community.
"It inspired the process of European integration," he said, "enabling the reconciliation of the peoples of the continent after the Second World War and the long period of stability and peace from which we benefit today."
"The spirit of the Schuman Declaration cannot fail to inspire all those with responsibilities in the European Union, called upon to face the social and economic consequences of the pandemic in a spirit of harmony and cooperation."
The second anniversary was that of St. John Paul's first visit to Africa 40 years ago. Francis said that on May 10, 1980, the Polish pope "gave voice to the cry of the people of the Sahel, harshly tried by drought."
He praised an initiative by young people to plant a million trees in the Sahel region, forming a "Great Green Wall" to combat the effects of desertification.
"I hope that many will follow the example of solidarity of these young people," he said.
The pope also noted that May 10 is Mother's Day in many countries.
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He said: "I want to remember all mothers with gratitude and affection, entrusting them to the protection of Mary, our heavenly Mother. My thoughts also go out to the mothers who have passed to the other life and accompany us from heaven."
He then called for a moment of silent prayer for mothers.
He concluded: "I wish everyone a good Sunday. Please don't forget to pray for me. Have a good lunch and goodbye for now."
Afterwards, he offered his blessing while overlooking an almost empty St. Peter's Square.