Swiss media outlet NZZ am Sonntag has previously reported that tens of millions of euros had been frozen by Swiss authorities in several bank accounts, in cooperation with Vatican investigators looking into the London property deal.
Italian media have reported that the frozen accounts include some belonging to Mincione, who has repeatedly denied any professional wrongdoing in his dealings with the Secretariat of State.
The search and seizure warrant on Mincione comes over a month after Vatican prosecutors arrested another Italian businessman, Gianluigi Torzi.
Torzi was arrested in Vatican City on June 5 for his role in brokering the final part of the secretariat's acquisition of 60 SA, the holding company which owns the building. Prosecutors have charged Torzi with extortion, embezzlement, aggravated fraud and money laundering.
In May, CNA reported that Fabrizio Tirabassi, a lay secretariat official who oversaw investments, was appointed a director of a company owned by Torzi while the businessman was finalizing the Vatican's purchase of the London property.
Torzi was released on bail June 15.
Following Torzi's arrest in June, Mincione distanced himself from Torzi, claiming the two were not personally connected and only linked professionally through the London deal. Mincione has also claimed that Torzi's involvement as a middle man in the final sale of the building came at the instruction of the Secretariat of State and that he had no involvement in Torzi's selection.
While denying any personal relationship with Torzi in June, Mincione also claimed to have a photograph of Torzi with Pope Francis. A similar image was subsequently released online.
Vatican action against Mincione is the latest development in a nearly 18-month-long ongoing investigation into financial dealings by the Secretariat of State.
A series of raids by Vatican authorities, beginning in October last year, have resulted in the suspension of several serving and former employees at the secretariat, including Tirabassi, as well as Msgr. Alberto Perlasca, whose home and office were raided earlier this year.