The vicar general said that there is "an undeclared persecution, an open persecution against the Church."
The identity of the man who perpetrated the attack on the chapel is unknown; he wore a hood while in the cathedral.
Several churches or chapels in Nicaragua have been vandalized in recent weeks.
On July 29, Our Lady of Perpetual Help chapel in Nindirí, about 13 miles southeast of Managua,was attacked. The perpetrators stole the tabernacle and the ciborium, smashed statues, and trampled the Hosts.
There was an attack on Our Lord of Veracruz parish in Masaya district, fewer than 20 miles southeast of Managua, July 25. The chapel was desecrated, and audio equipment and money boxes were stolen.
Nicaragua's crisis began in 2018 after president Daniel Ortega announced social security and pension reforms. The changes were soon abandoned in the face of widespread, vocal opposition, but protests only intensified after more than 40 protestors were killed by security forces.
The pension reforms which triggered the unrest were modest, but protests quickly turned to Ortega's authoritarian bent.
Ortega has been president of Nicaragua since 2007, and oversaw the abolition of presidential term limits in 2014.
Ortega was a leader in the Sandinista National Liberation Front, which had ousted the Somoza dictatorship in 1979 and fought US-backed right-wing counterrevolutionaries during the 1980s. Ortega was also leader of Nicaragua from 1979 to 1990.
The Nicaraguan clergy have not hesitated to call out the government for its violent repression of protests and for human rights abuses, making the Church an adversary in the eyes of the government.
On various occasions both bishops and priests have been physically assailed by pro-government supporters, and other acts of vandalism and intimidation have occurred.
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Managua's cathedral was also the site of a hunger strike in November 2019. The hunger strikers were calling for the release of their relatives, whom they believe to be political prisoners. Pro-government forces besieged the cathedral in response.