Pope Francis noted that Jesus ended his reply by saying: "The whole law and the prophets depend on these two commandments."
"This means that all the precepts the Lord has given to his people must be related to love of God and neighbor," he said.
"In fact, all the commandments serve to implement and express that twofold indivisible love."
The pope said that love for God is expressed above all in prayer, especially adoration.
"We neglect the adoration of God so much," he lamented. "We make the prayer of thanksgiving, the supplication to ask for something... but we neglect adoration. Worshiping God is the very core of prayer."
The pope added that we also forget to act charitably towards others. We fail to listen to others because we find them boring or because they use up our time. "But we always find time to chat," he observed.
The pope said that in Sunday's Gospel Jesus directs his followers to the source of love.
"This wellspring is God himself, to be loved completely in a communion that nothing and no one can break. A communion that is a gift to be invoked each day, but also a personal commitment not to let our lives become enslaved by the idols of the world," he said.
"And the proof of our journey of conversion and holiness always consists in love of neighbor ... The proof that I love God is that I love my neighbor. As long as there is a brother or sister to whom we close our hearts, we will still be far from being disciples as Jesus asks us. But his divine mercy does not allow us to be discouraged, but rather calls us to begin anew each day to live the Gospel consistently."
After the Angelus, Pope Francis greeted the residents of Rome and pilgrims from around the world who had gathered in the square below, spaced out to prevent the spread of the coronavirus. He singled out a group called "Cell of Evangelization," attached to the Rome Church of St. Michael the Archangel.
He then announced the names of 13 new cardinals, who will receive the red hat at a consistory on Nov. 28, the vigil of the First Sunday of Advent.
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The pope concluded his Angelus reflection by saying: "May the intercession of Most Holy Mary open our hearts in order to welcome the 'great commandment,' the twofold commandment of love, which encapsulates all of God's Law and on which our salvation depends."