Even just everyday life, "marked by fragility, weakness and difficulties, a life at times wounded and pained by ingratitude and misunderstanding," can be filled with sorrow, he said.
Jesus, Pope Francis said, is proclaiming blessed all those who trust in the Lord despite everything, who do not harden their hearts in response to pain, but "patiently hope for God's comfort."
He explained that the saints are "the most authoritative witnesses of Christian hope, because they lived it fully in their lives, amidst joys and sufferings, putting into practice the Beatitudes that Jesus preached."
Francis also pointed to the Virgin Mary, who is called the Queen of All Saints, and who teaches everyone how to follow the example of her children the saints.
"May she help us nourish the desire for holiness, walking the way of the Beatitudes," he said.
After the Angelus, Pope Francis noted the beatification of Fr. Michael McGivney in Hartford, Connecticut, on Oct. 31.
"Dedicated to evangelization, he did everything possible to provide for the needs of those in need, promoting reciprocal aid. May his example be an impetus for us to always be witnesses of the Gospel of charity," he said, asking for a round of applause for the new Bl. Michael McGivney.
The pope asked for continued prayers for the victims of "tragic" clashes in Nagorno-Karabakh, where people continue to lose their lives, and homes and places of worship have been destroyed.
He said he is near to all who are suffering and invited everyone to ask the intercession of the saints for peace in that region.
The pope also asked for prayers for victims of a recent earthquake in the area of the Aegean Sea.
He closed his weekly Angelus prayer and address by announcing he will say Mass in the Vatican's Teutonic Cemetery on Nov. 2 for the suffrage of the deceased. "I unite myself spiritually to those who, while observing the health regulations which are important, go to pray near the tombs of their dear ones in every part of the world," Francis said.
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"I wish all of you a Happy Feast in the spiritual company of the saints."