"If she could see this place here in Rome, she would see part of her dream realized," Alan Holdren, EWTN News Bureau Chief, told Vatican Radio.
"I think Mother would be very, very pleased to see this development in Rome," he said. "It was always her hope that the network could be a vehicle for bringing news and information about the Holy Father and the Vatican to our audience around the world."
Cardinal Sean O'Malley of Boston also saw the new Rome office as part of Mother Angelica's legacy.
"I am convinced that Mother Angelica is now happy in heaven thinking that after all his work, there is now finally this place here in Rome," Cardinal O'Malley told Vatican Radio. "The story of Mother Angelica is the story of a miracle. A cloistered nun has managed to do what the bishops and the U.S. Catholic foundations have failed to do."
"EWTN is an important reality in the United States to reach Catholics," the cardinal continued. "To have a headquarters here in Rome will help a lot to communicate to our people the message of the Holy Father and what happens here in Rome."
Cardinal O'Malley said EWTN faces the challenge of communicating the faith to new generations.
"In the U.S. we now have a huge Hispanic population, and we are very pleased that EWTN also has programs in Spanish, for our migrants," he said.
The beneficiaries of EWTN are truly international. During Mother Teresa's canonization, her Missionaries of Charity sisters in India were watching the EWTN broadcast from St. Peter's Square.
"That would be enough to motivate our work," commented Holdren.
He noted the world's many crises, including those in the Middle East.
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"We serve an evangelical voice, we serve the voice of Christ, we serve the Pope's message," he said.
"To reach these places of crisis is a challenge. Through the satellite that Mother Angelica bought many years ago, we were able to reach these countries."
"The challenge is to keep this widespread reach, but also reach people in modern Western society. In the face of so many problems and so many challenges, there are many hopes. We want to reach out with this Gospel message to deliver that truth which we believe leads everyone to the salvation that it accompanies."
EWTN Global Catholic Network is now in its 36th year. Based in Irondale, Alabama, it is the largest religious media network in the world.